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On November 1, 2017, the White House announced the release of the Fentanyl Safety Recommendations for First Responders. The Recommendations provide first responders with unified, scientific, evidence-based recommendations to protect themselves when the presence of fentanyl is suspected. The National Sheriffs' Association supports the release of these Recommendations as a critical first step in keeping first responders safe in the field. The Recommendations are the result of a Federal Interagency Working Group coordinated by the White House National Security Council. Stakeholder associations and organizations representing the medical, public health, law enforcement, Fire/EMS, and occupational safety and health disciplines provided invaluable input to inform the Interagency Working Group’s efforts, and their feedback helped ensure the Recommendations are operationally relevant, appropriately tailored to first responders, and conveyed in a user-friendly one-page format. NSA is one of 24 associations/organizations offering collaborative support for the Recommendations.